ACT! Is an excellent product with loads of 3rd party addons to get it to do pretty much whatever you want.
The newest version is out at the beginning of Sept 2011.

The installation can be a bit awkward, you need to shut down all AV’s when installing and it’s best to have as few unnecessary programs and services running.

I’m currently researching how to integrate Evernote with ACT!, make the most out of the best of both products.