Thanks for mentioning Reeder — I had no idea they released a desktop version! I’ve been using Reeder on my iPhone and iPad (before I sold it) over the past year, and it’s completely changed my blog/news reading habits.
What I love about the app, and others like Twitter and Sparrow, is that they’ve implemented a great UI with a slick design. I hope this is the future of OS X in general — simple, elegant and highly intuitive.
Up until now, I’ve been using NetNewsWire (ad-supported free version). It’s functions decently enough, but looks like it belongs on WinXP.